ReSARCH is Knowledge

Professor Dr. Bernard Cambier is a researcher and clinician whose work spans multiple fields, including dermatology, plastic and reconstructive surgery, vascular biology, and genetic research. His extensive contributions have led to advancements in minimally invasive treatments, surgical techniques, and the understanding of cellular and molecular mechanisms in medicine.

In dermatology, he has been at the forefront of laser research, particularly with Erbium:YAG (Er:YAG) laser applications for skin rejuvenation, scar revision, and tattoo removal. 

Dr. Cambier has significantly contributed to the field of plastic and reconstructive surgery, particularly in breast surgery techniques. 

In vascular biology, his work has deepened the understanding of fibroblast behavior and vascular remodeling. 

Additionally, his research into genetic factors affecting surgery has explored the role of haptoglobin polymorphism in cardiovascular procedures. 

Dr. Cambier’s multidisciplinary research has played a crucial role in advancing medical science, bridging fundamental research with clinical applications. His contributions have led to improved patient outcomes in dermatology, reconstructive surgery, and vascular medicine, reinforcing the importance of innovation and scientific inquiry in healthcare.

Dr Cambier has made significant contributions to medical research, particularly in the areas of haptoglobin polymorphism and vascular biology.

In collaboration with Dr. Joris Delanghe and colleagues, Dr. Cambier co-authored the study titled "Haptoglobin polymorphism, a genetic risk factor in coronary artery bypass surgery," published in Atherosclerosis in 1997. This research investigated the relationship between haptoglobin phenotypes and the extent of coronary lesions in male patients undergoing coronary artery bypass grafting (CABG). The findings suggested that certain haptoglobin polymorphisms might be associated with an increased risk of complications post-surgery, indicating the potential value of haptoglobin typing in preoperative risk assessment. 

Dr. Bernard Cambier has collaborated with Dr. Philippe Van Cauwelaert and Dr. Mark Kockx on research focusing on fibroblast behavior and vascular biology. Their joint efforts have contributed to a deeper understanding of the cellular mechanisms involved in vascular remodeling and repair processes.

In a notable study titled "Adventitial myofibroblast cells translocate to the neointima in healing rat vein grafts," published in Cardiovascular Research, the team investigated the role of adventitial myofibroblasts in vein graft remodeling. They discovered that these cells migrate from the adventitia to the neointima during the healing process, contributing to neointimal formation. This finding provided valuable insights into the cellular dynamics of vein graft adaptation and the development of intimal hyperplasia.

Additionally, their research explored the impact of hemodynamic forces on smooth muscle cell behavior in vein grafts. In the study "Hemodynamic Influence on Smooth Muscle Cell Kinetics and Phenotype During Early Vein Graft Adaptation," published in Journal of Vascular Research, they examined how changes in blood flow affect smooth muscle cell proliferation and phenotype during the early stages of vein graft adaptation. The findings highlighted the significance of hemodynamic factors in vascular remodeling and the potential role of fibroblast-like cells in this process.

These collaborative studies by Dr. Cambier, Dr. Van Cauwelaert, and Dr. Kockx have advanced the understanding of fibroblast involvement in vascular pathology and repair mechanisms, offering potential avenues for therapeutic interventions in vascular diseases.

Dr. Bernard Cambier has made significant contributions to breast surgery, focusing on innovative techniques and treatments to enhance patient outcomes. Below is a summary of his notable publications in this field:

1. Mastopexy Under Local Anesthesia

In a case series and systematic review titled "Mastopexy under local anesthesia," Dr. Cambier and his colleagues explored the feasibility of performing breast lift procedures without general anesthesia. The study concluded that mastopexies can be safely conducted under local anesthesia, with patients experiencing low perioperative and postoperative pain scores. This approach offers a viable option for individuals seeking breast lifts with minimal anesthesia-related risks. 

2. Treatment of Severe or Recurrent Inverted Nipple

Dr. Cambier co-authored a study titled "Treatment of the severe or recurrent inverted nipple by interposition of a resorbable polydioxanone sheet." This research addressed the functional and aesthetic concerns associated with inverted nipples. The proposed technique involves using a resorbable polydioxanone sheet to correct the inversion, providing a reliable solution with favorable outcomes. 

3. Management of Exposed Breast Prosthesis

In the article "The exposed breast prosthesis at the infra-mammary region: Treatment by local flaps," Dr. Cambier and his team presented cases where exposed breast implants were successfully salvaged using local flaps. This method provided tissue support in critical areas, allowing for the preservation of the original implant and reducing psychological distress for patients. 

4. Granulomatous Mastitis Caused by Corynebacterium Bovis

In a case report titled "Granulomatous mastitis caused by Corynebacterium bovis mimicking inflammatory breast cancer," Dr. Cambier and his colleagues discussed the clinical course, diagnosis, and treatment of a patient presenting with progressive unilateral breast pain. The study highlighted the importance of considering a broad range of differential diagnoses for breast pain and emphasized thorough clinical and imaging assessments to guide appropriate management strategies. 

Dr. Cambier's research reflects his dedication to advancing breast surgery techniques and improving patient care through innovative and less invasive approaches.

Dr. Bernard Cambier has conducted extensive research on the applications of the Erbium:YAG (Er:YAG) laser in dermatology, with a particular focus on minimally invasive skin rejuvenation and the treatment of traumatic tattoos. His collaborative efforts with renowned researchers such as Dr. Karin Kunzi-Rapp, Dr. Fabrice Rogge, Dr. Jean-Luc Lévy, and Dr. Christine Dierickx have significantly advanced laser-based dermatological treatments.

In collaboration with Dr. Karin Kunzi-Rapp and colleagues, Dr. Cambier co-authored a study titled "Minimally Invasive Skin Rejuvenation with Erbium:YAG Laser Used in Thermal Mode," published in Lasers in Surgery and Medicine. This research evaluated the efficacy and safety of the Er:YAG laser operating in a thermal, sub-ablative mode for skin rejuvenation. The study involved treating patients with periorbital and perioral rhytides, as well as those with post-traumatic or acne scars.

The study protocol included two treatments spaced two months apart, with follow-ups extending up to 12 months post-treatment. Results showed significant improvements in skin texture and wrinkle reduction, with histological analyses confirming new collagen formation in the upper dermis. The procedure was well-tolerated, and minimal side effects were reported, reinforcing the Er:YAG laser's potential for safe and effective non-invasive skin treatments.

Dr. Cambier also collaborated with Dr. Jean-Luc Lévy and Dr. Christine Dierickx in a study titled "Non-ablative Skin Rejuvenation with Er:YAG Laser Used in Non-Ablative Mode." This research focused on evaluating the non-ablative Er:YAG laser’s effectiveness in improving skin texture and reducing visible signs of aging without significant damage to the epidermis.

The findings demonstrated that non-ablative Er:YAG laser treatments could stimulate collagen remodeling, leading to visible improvements in skin tone and texture with minimal downtime. This technique offers an attractive alternative for patients seeking skin rejuvenation without prolonged recovery periods.

Dr. Cambier extended his research into the treatment of traumatic tattoos using laser technology. In collaboration with Dr. Fabrice Rogge, he published the study "Traumatic Tattoo: Use of the Variable Pulsed Erbium:YAG Laser," in Photomedicine and Laser Surgery. This study explored the efficacy of the Er:YAG laser in removing traumatic tattoos from facial areas.

The treatment protocol involved using an Er:YAG laser at a fluence of 5 J/cm² to achieve selective dermabrasion without damaging the surrounding skin. Results indicated near-complete clearance of tattoos after a single session, with no scarring, atrophy, or pigmentation disturbances. The study concluded that the Er:YAG laser presents a safe and highly effective alternative to traditional dermabrasion and other laser treatments for traumatic tattoo removal.